https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49007 Wed 03 May 2023 12:17:36 AEST ]]> Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44746 Tue 21 Mar 2023 16:53:58 AEDT ]]> Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45201 P = 3.96 x 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.]]> Thu 27 Oct 2022 15:06:39 AEDT ]]> Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46603 Fri 25 Nov 2022 16:41:41 AEDT ]]>